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the expertise and judgment of your physician, pharmacist or other health care provider.
It should not be construed to indicate that the use of the medication(s) shown are
safe, appropriate, or effective for you.
The information shown is general and does not cover all directions, possible drug integrations, or precautions.
Information on this site cannot be used for self-treatment and/or self-diagnosis.
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We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of
the information on this site nor will we be held responsible for consequences of self-treatment.
Consult your health care provider before using any drug.
The following information is a summary about
Zyban. It is not intended to replace a doctor's instructions.
(bupropion) is a round purple film coated tablet with the
engraving of “ZYBAN 150” on its surface. It is a sustained
released tablet manufactured in only a single strength (150
AM I ADDICTED TO CIGARETTES?
You may be addicted to cigarettes if you experience one or more of
the following signs:
You continue to smoke despite the desire to quit.
You have made a serious, but unsuccessful, attempt to stop using
tobacco or permanently reduce the amount you use.
Your attempts to stop smoking have led to physical withdrawal
symptoms, including a craving for tobacco, anxiety, irritability,
restlessness, difficulty concentrating, headaches, drowsiness, and
You develop a "tolerance" for tobacco. Smoking the same number of
cigarettes produces less effect over time, making it necessary to
increase the number of cigarettes you smoke to achieve the desired
You have continued to use tobacco even when you have a serious
physical problem (such as heart or lung disease) that you know is
worsened by tobacco.
When smokers who are addicted to cigarettes quit smoking, they may
suffer from symptoms that can be psychological, emotional, or
physical in nature. This is called withdrawal. They may experience
irritability, anxiety, difficulty concentrating, restlessness, or
HOW DOES ZYBAN WORK?
The mechanism by which ZYBAN enhances the ability of patients
to abstain from smoking is not totally known. It is presumed that it
inhibits specific chemical receptors in the brain that mediate the
craving for smoking.
HOW EFFECTIVE IS ZYBAN?
Clinical studies have shown that ZYBAN reduces the craving
for cigarettes as well as withdrawal symptoms associated with
smoking cessation to a significant degree when compared with
placebo. Reductions in the following withdrawal symptoms were most
pronounced: irritability, frustration or anger, anxiety, difficulty
concentrating, restlessness and depressed mood. In clinical studies
it has been demonstrated that ZYBAN achieves the best results
in diminishing the withdrawal symptoms of nicotine, significant
reduction in craving for cigarettes and an elevated abstinence rate
in the long term. In addition, your chances of quitting with
ZYBAN greatly depend on your commitment to quitting.
CAN I DO ANYTHING TO MAKE ZYBAN MORE EFFECTIVE?
Yes, ZYBAN while effective medication may work best if you
are enrolled in a smoking cessation program or behavioral support
HOW SHOULD I TAKE ZYBAN?
The usual recommended dosage is to take one 150-mg tablet in the
morning for the first 3 days. On the fourth day, begin taking one
150-mg tablet in the morning and one 150-mg tablet in the early
evening. Doses should be taken at least 8 hours apart.
Never take an "extra" dose of ZYBAN. If you forget to take a
dose, do not take an extra tablet to "catch up" for the dose you
forgot. Wait and take your next tablet at the regular time. Do not
take more tablets than prescribed. This is important so you do not
increase your chance of having a seizure.
It is important to swallow ZYBAN tablets whole. Do not chew,
divide, or crush tablets. You may take ZYBAN with or without
HOW LONG DO I REMAIN ON ZYBAN?
For most patients, it is recommend that you stay on ZYBAN for
at least 7 to 12 weeks to help support long-term success. It may be
necessary to stay on ZYBAN for a longer period, depending
upon the rapidity with which you withdraw from nicotine. You've
probably been smoking for some time, and your body has become
accustomed to it. ZYBAN helps reduce withdrawal symptoms as
you remove cigarettes from your life. It's important to remain on
ZYBAN for at least 7 to 12 weeks but it may require up to 6
months of therapy if your dependence on nicotine is great.
WHEN SHOULD I STOP SMOKING?
It takes about 1 week for ZYBAN to reach the right levels in
your body to be effective. So, to maximize your chance of quitting,
you should not stop smoking until you have been taking ZYBAN
for 1 week. You should set a date to stop smoking during the second
week you're taking ZYBAN.
CAN I DRINK OR SMOKE WHILE TAKING ZYBAN?
It is best not to drink alcohol at all, or to drink very little,
while taking ZYBAN. People who drink a lot of alcohol and
then suddenly stop drinking, may increase their risk of developing a
It is not physically dangerous to smoke and use ZYBAN at the
same time. However, continuing to smoke after the date you set to
stop smoking will seriously reduce your chance of breaking the
CAN I TAKE ZYBAN IF I HAVE MILD-TO-MODERATE CHRONIC BRONCHITIS
Yes, ZYBAN combined with a behavior modification program has
been shown to help people with COPD quit smoking. It is important to
participate in the behavior program, counseling, or other support
program that is offered in your community.
ARE THERE ANY SPECIAL CONCERNS FOR WOMEN?
ZYBAN is not recommended for women who are pregnant or
breast-feeding. Women should probably not begin a smoking cessation
program with ZYBAN if they are breast-feeding or intend to
ARE THERE ANY SPECIAL CONCERNS FOR PATIENTS WITH LIVER OR KIDNEY
If you have liver or kidney problems, let us know on your medical
history/personal profile before taking ZYBAN. Depending on
the severity of your condition, the dosage of the drug my need to be
CAN ZYBAN BE USED AT THE SAME TIME AS NICOTINE PATCHES?
Yes, ZYBAN and nicotine patches can be used at the same time
but should only be used together under the supervision of your
healthcare professional. Using ZYBAN and nicotine patches
together may raise your blood pressure. Your healthcare professional
will probably want to check your blood pressure regularly to make
sure that it stays within acceptable levels. Do Not Smoke At Any
Time if you are using the nicotine patch or any other nicotine
product along with ZYBAN. It is possible to get too much
nicotine and experience serious side effects.
CAN I SMOKE WHILE USING ZYBAN?
It is not physically dangerous to smoke and use ZYBAN at he
same time. However, continuing to smoke after the date you set to
stop smoking will seriously reduce your chances of breaking the
ZYBAN AND SLEEPING:
If you have trouble sleeping, try not to take your medication too
close to bedtime. If you're taking two tablets each day, take one
early in the day and the second one in the late afternoon or very
early evening. Be sure that you take them at least 8 hours apart.
Also, try to avoid drinking any beverages that contain caffeine in
the late afternoon or evening. This includes coffee, tea, and many
ZYBAN AND SEIZURES:
There is an increased risk of developing a seizure when taking
ZYBAN, although this risk is quite small. Nonetheless, it is
important to let us know on your medical history/personal profile
about any other prescription or over-the-counter medications that
you are taking.
SIDE EFFECTS OF ZYBAN:
The most common side effects from ZYBAN are dry mouth and
some difficulty sleeping. If you experience dry mouth while you're
taking ZYBAN, you may be more comfortable if you drink plenty
of water. Also, some people find that sucking on lozenges or chewing
sugarless gum helps keep your mouth moist.
The most common side effects that caused people to stop taking
ZYBAN during clinical studies were shakiness and skin rash. Stop
taking ZYBAN if you have signs of an allergic reaction such
as a rash, hives, or difficulty in breathing.
WHO SHOULD NOT TAKE ZYBAN:
You should not take ZYBAN if you:
are taking WELLBUTRIN (bupropion HCl) Tablets or
WELLBUTRIN SR (bupropion HCl) Sustained-Release Tablets.
are taking any other medicines that contain bupropion HCl.
have or have had a seizure disorder (for example, epilepsy).
have or have had an eating disorder.
are currently taking or have recently taken a monoamine oxidase
are allergic to bupropion HCl.