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What is Buphenyl ?


USES: This medication helps remove excess nitrogen from the body. In addition to diet, this medication is used to manage the effects of certain metabolic disorders (urea cycle disorders).

HOW TO USE: Take by mouth or by feeding tube (nasogastric tube or gastrostomy), as directed. Dosage is based on your size/weight, condition and response to therapy. Generally the total daily dose is divided into equal amounts and given with each meal (i.e., three times per day). The powder should be mixed with solid or liquid food. Do not mix with acidic beverages (e.g., orange juice). Shake powder before use.

SIDE EFFECTS: Loss of appetite may occur. If this effect persists or worsens, notify your doctor promptly. Report promptly: changes in menstrual period, body odor or taste changes. Unlikely but report promptly: mental/mood changes, tiredness or drowsiness, weakness, dizziness, headache. Very unlikely but report promptly: stomach pain, bloody stools, persistent sore throat or fever, unusual bruising, irregular heartbeat, rash, hearing changes, fainting, swelling. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor your medical history, including: any allergies, heart disease (congestive heart failure), kidney disease, liver disease, swelling (edema). Each 1 gram of this medicine contains 124 mg of sodium. Use with caution in cases of salt-restricted diets. Consult your doctor. Limit alcohol intake, as it may intensify certain drug effects. Caution is advised when performing tasks requiring alertness (e.g., driving) as this drug may cause drowsiness or dizziness. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug is excreted into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Tell your doctor of all prescription and nonprescription medication you may use, especially: probenecid, haloperidol, corticosteroids (e.g., prednisone), seizure medicine, (e.g., valproic acid). Tell your doctor if you take any drugs that make you drowsy, such as: sedatives, tranquilizers, certain psychiatric medications (e.g., chlorpromazine, amitriptyline), narcotic pain relievers (e.g., codeine), certain antihistamines (e.g., diphenhydramine). Many nonprescription medicines (such as cough-cold products) contain antihistamines. Check labels carefully and consult your pharmacist. Do not start or stop any medicine without doctor or pharmacist approval.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately.

MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE: Store at room temperature between 59 and 86 degrees F (15 - 30 degrees C) away from light and moisture.

NOTES: Do not share this medication with others. Laboratory and/or medical tests should be performed routinely to monitor for side effects and response to therapy.

IMPORTANT NOTE: The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

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