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Butalbital (generic Fioricet)


IMPORTANT NOTE:The Butalbital that may be prescribed through medical services is made by manufacturers from the DEA exemption list only.

Butalbital (combined with acetaminophen and caffeine) is used to relieve tension headaches. It is also commonly prescribed for the treatment of pain.

Quantity/Dose Price Medical Services Fee Shipping Total
30 Apap-Caff  50-325-40mg Tab$ 34.81$ 39.95$ 4.99$ 79.75
60 Apap-Caff  50-325-40mg Tab$ 65.01$ 39.95$ 4.99$ 109.95
90 Apap-Caff  50-325-40mg Tab$ 95.01$ 39.95$ 4.99$ 139.95
120 Apap-Caff  50-325-40mg Tab$ 125.01$ 39.95$ 4.99$ 169.95

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IMPORTANT NOTE: This information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other health care provider. It should not be construed to indicate that the use of the medication(s) shown are safe, appropriate, or effective for you. The information shown is general and does not cover all directions, possible drug integrations, or precautions. Information on this site cannot be used for self-treatment and/or self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care provider. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site nor will we be held responsible for consequences of self-treatment. Consult your health care provider before using any drug.

What is Butalbital?
The Butalbital name used in this document refers to the Acetaminophen-Butalbital-Caffeine combination found in the following brand-name medications: Fioricet, Esgic, and Endolor. The Butalbital combination is used to treat certain types of headaches and migraines as well as mild to moderate pain. Federal law prohibits the transfer of Butalbital to any person other than the patient for whom it was prescribed. Do not share Butalbital with any one else.

What should my health care professional know before I Butalbital?
They need to know if you have any of these conditions:
  • anemia
  • attempted suicide
  • diabetes mellitus
  • drink more than 3-alcohol containing drinks per day
  • drug abuse or use of illicit drugs
  • heart disease
  • high or low blood pressure
  • infection
  • kidney disease
  • liver disease
  • lung disease or breathing difficulties
  • mental depression or mental problems
  • peptic ulcer disease
  • porphyria
  • thyroid disease
  • an unusual or allergic reaction to acetaminophen, butalbital or other barbiturates, caffeine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding


  • How should I take Butalbital?
    Take Butalbital tablets or capsules by mouth. Follow the directions on the prescription label. Swallow the tablets or capsules with a drink of water. If Butalbital upsets your stomach, take it with food or milk. Do not take Butalbital more often than directed. Contact your pediatrician or health care professional regarding the use of Butalbital in children. Special care may be needed. Do not share Butalbital with anyone.

    What if I miss a dose of Butalbital?
    If it is almost time for your next dose, take only that dose. Do not take double or extra doses of Butalbital.

    What drug(s) may interact with Butalbital?
  • alcohol
  • cyclosporine
  • corticosteroids
  • female hormones, including contraceptive or birth control pills
  • grapefruit juice
  • medicines for high blood pressure or other heart problems
  • medicines for depression or other mental health problems
  • medicines for pain
  • medicines to control heart rhythm
  • quinine
  • seizure medicine
  • theophylline
  • warfarin


  • Because Butalbital can cause drowsiness, other medicines that also cause drowsiness may increase this effect of Butalbital. Some other medicines that cause drowsiness are:
  • alcohol-containing medicines
  • certain antidepressants or tranquilizers
  • muscle relaxants
  • certain antihistamines used in cold medicines


  • Tell your prescriber or health care professional about all other medicines that you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also, tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way Butalbital works. Check with your health care professional before stopping or starting any of your medicines.

    What side effects may I notice from taking Butalbital?
    Side effects that you should report to your prescriber or health care professional as soon as possible:
  • bone tenderness
  • changes in behavior, mood, or mental ability
  • seizures
  • difficulty breathing or shortness of breath
  • eye problems, very small or enlarged centers to the eyes
  • fever, sore throat
  • hallucinations
  • lightheadedness or fainting spells
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • skin rash, itching, hives
  • slow or fast heartbeat
  • swelling of the face or lips
  • unusual bleeding or bruising, pinpoint red spots on the skin
  • unusual tiredness or weakness
  • yellowing of skin or eyes


  • Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
  • confusion, agitation
  • trembling
  • increased frequency passing urine
  • constipation
  • clumsiness, unsteadiness, or a "hang-over" effect
  • difficulty sleeping or nightmares
  • drowsiness, dizziness
  • headache
  • irritability, nervousness
  • nausea or vomiting


  • What should I watch for while taking Butalbital?
    Visit your prescriber or health care professional for regular checks on your progress. After taking Butalbital you may get a residual hangover effect that leaves you drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how Butalbital affects you. To reduce dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Avoid alcoholic drinks while you are taking Butalbital. Alcohol can increase possible damage to your liver and can increase possible unpleasant effects. Butalbital can stop birth control pills (oral contraceptives) from working properly. Use another method of birth control while you are taking Butalbital. If you have been taking caffeine or butalbital on a regular basis, you can get withdrawal symptoms if you stop taking them. Symptoms include tiredness, dizziness, headache, anxiety, or nervousness. Try to avoid foods and drinks that contain caffeine while taking Butalbital. Do not take Butalbital with other non-prescription medicines, especially cold and allergy medicines without asking your prescriber or health care professional for advice. Grapefruit juice may increase the effects of Butalbital. Many non-prescription medicines contain acetaminophen as an ingredient. Always read the labels carefully to avoid taking an accidental overdose, which can be dangerous. If you are receiving cancer chemotherapy or other immunosuppression medicine, do not take Butalbital with out checking with your prescriber or health care professional. Butalbital may hide the signs of an infection such as fever or pain. If you are going to have surgery, tell your prescriber or health care professional that you are taking Butalbital.

    Where can I keep Butalbital?
    Keep out of the reach of children in a container that small children cannot open. Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused Butalbital after the expiration date.

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