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Bupropion HCL SR


Bupropion HCL SR is a smoking cessation aid used to help you stop smoking.

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IMPORTANT NOTE: This information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other health care provider. It should not be construed to indicate that the use of the medication(s) shown are safe, appropriate, or effective for you. The information shown is general and does not cover all directions, possible drug integrations, or precautions. Information on this site cannot be used for self-treatment and/or self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care provider. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site nor will we be held responsible for consequences of self-treatment. Consult your health care provider before using any drug.

The following information is a summary about Bupropion HCL SR. It is not intended to replace a doctor's instructions.

Bupropion HCL SR (bupropion) is a round purple tablet with the imprint of E 415 on its surface. It is a sustained released tablet in 150 milligrams.

AM I ADDICTED TO CIGARETTES?

You may be addicted to cigarettes if you experience one or more of the following signs:

- You continue to smoke despite the desire to quit.

- You have made a serious, but unsuccessful, attempt to stop using tobacco or permanently reduce the amount you use.

- Your attempts to stop smoking have led to physical withdrawal symptoms, including a craving for tobacco, anxiety, irritability, restlessness, difficulty concentrating, headaches, drowsiness, and stomach upset.

- You develop a "tolerance" for tobacco. Smoking the same number of cigarettes produces less effect over time, making it necessary to increase the number of cigarettes you smoke to achieve the desired sensation.

- You have continued to use tobacco even when you have a serious physical problem (such as heart or lung disease) that you know is worsened by tobacco.

WITHDRAWAL:

When smokers who are addicted to cigarettes quit smoking, they may suffer from symptoms that can be psychological, emotional, or physical in nature. This is called withdrawal. They may experience irritability, anxiety, difficulty concentrating, restlessness, or depression.

HOW DOES BUPROPION WORK?

The mechanism by which BUPROPION enhances the ability of patients to abstain from smoking is not totally known. It is presumed that it inhibits specific chemical receptors in the brain that mediate the craving for smoking.

HOW EFFECTIVE IS BUPROPION?

Clinical studies have shown that BUPROPION reduces the craving for cigarettes as well as withdrawal symptoms associated with smoking cessation to a significant degree when compared with placebo. Reductions in the following withdrawal symptoms were most pronounced: irritability, frustration or anger, anxiety, difficulty concentrating, restlessness and depressed mood. In clinical studies it has been demonstrated that BUPROPION achieves the best results in diminishing the withdrawal symptoms of nicotine, significant reduction in craving for cigarettes and an elevated abstinence rate in the long term. In addition, your chances of quitting with BUPROPION greatly depend on your commitment to quitting.

CAN I DO ANYTHING TO MAKE BUPROPION MORE EFFECTIVE?

Yes, BUPROPION while effective medication may work best if you are enrolled in a smoking cessation program or behavioral support program.

HOW SHOULD I TAKE BUPROPION?

- The usual recommended dosage is to take one 150-mg tablet in the morning for the first 3 days. On the fourth day, begin taking one 150-mg tablet in the morning and one 150-mg tablet in the early evening. Doses should be taken at least 8 hours apart.

- Never take an "extra" dose of BUPROPION. If you forget to take a dose, do not take an extra tablet to "catch up" for the dose you forgot. Wait and take your next tablet at the regular time. Do not take more tablets than prescribed. This is important so you do not increase your chance of having a seizure.

- It is important to swallow BUPROPION tablets whole. Do not chew, divide, or crush tablets. You may take BUPROPION with or without food.

HOW LONG DO I REMAIN ON BUPROPION?

For most patients, it is recommend that you stay on BUPROPION for at least 7 to 12 weeks to help support long-term success. It may be necessary to stay on BUPROPION for a longer period, depending upon the rapidity with which you withdraw from nicotine. You've probably been smoking for some time, and your body has become accustomed to it. BUPROPION helps reduce withdrawal symptoms as you remove cigarettes from your life. It's important to remain on BUPROPION for at least 7 to 12 weeks but it may require up to 6 months of therapy if your dependence on nicotine is great.

WHEN SHOULD I STOP SMOKING?

It takes about 1 week for BUPROPION to reach the right levels in your body to be effective. So, to maximize your chance of quitting, you should not stop smoking until you have been taking BUPROPION for 1 week. You should set a date to stop smoking during the second week you're taking BUPROPION.

CAN I DRINK OR SMOKE WHILE TAKING BUPROPION?

It is best not to drink alcohol at all, or to drink very little, while taking BUPROPION. People who drink a lot of alcohol and then suddenly stop drinking, may increase their risk of developing a seizure.

It is not physically dangerous to smoke and use BUPROPION at the same time. However, continuing to smoke after the date you set to stop smoking will seriously reduce your chance of breaking the smoking habit.

CAN I TAKE BUPROPION IF I HAVE MILD-TO-MODERATE CHRONIC BRONCHITIS AND/OR EMPHYSEMA?

Yes, BUPROPION combined with a behavior modification program has been shown to help people with COPD quit smoking. It is important to participate in the behavior program, counseling, or other support program that is offered in your community.

ARE THERE ANY SPECIAL CONCERNS FOR WOMEN?

BUPROPION is not recommended for women who are pregnant or breast-feeding. Women should probably not begin a smoking cessation program with BUPROPION if they are breast-feeding or intend to become pregnant.

ARE THERE ANY SPECIAL CONCERNS FOR PATIENTS WITH LIVER OR KIDNEY PROBLEMS?

If you have liver or kidney problems, let us know on your medical history/personal profile before taking BUPROPION. Depending on the severity of your condition, the dosage of the drug my need to be adjusted.

CAN BUPROPION BE USED AT THE SAME TIME AS NICOTINE PATCHES?

Yes, BUPROPION and nicotine patches can be used at the same time but should only be used together under the supervision of your healthcare professional. Using BUPROPION and nicotine patches together may raise your blood pressure. Your healthcare professional will probably want to check your blood pressure regularly to make sure that it stays within acceptable levels. Do Not Smoke At Any Time if you are using the nicotine patch or any other nicotine product along with BUPROPION. It is possible to get too much nicotine and experience serious side effects.

CAN I SMOKE WHILE USING BUPROPION?

It is not physically dangerous to smoke and use BUPROPION at he same time. However, continuing to smoke after the date you set to stop smoking will seriously reduce your chances of breaking the smoking habit.

BUPROPION AND SLEEPING:

If you have trouble sleeping, try not to take your medication too close to bedtime. If you're taking two tablets each day, take one early in the day and the second one in the late afternoon or very early evening. Be sure that you take them at least 8 hours apart. Also, try to avoid drinking any beverages that contain caffeine in the late afternoon or evening. This includes coffee, tea, and many sodas.

BUPROPION AND SEIZURES:

There is an increased risk of developing a seizure when taking BUPROPION, although this risk is quite small. Nonetheless, it is important to let us know on your medical history/personal profile about any other prescription or over-the-counter medications that you are taking.

SIDE EFFECTS OF BUPROPION:

The most common side effects from BUPROPION are dry mouth and some difficulty sleeping. If you experience dry mouth while you're taking BUPROPION, you may be more comfortable if you drink plenty of water. Also, some people find that sucking on lozenges or chewing sugarless gum helps keep your mouth moist.

The most common side effects that caused people to stop taking BUPROPION during clinical studies were shakiness and skin rash. Stop taking BUPROPION if you have signs of an allergic reaction such as a rash, hives, or difficulty in breathing.

WHO SHOULD NOT TAKE BUPROPION:

You should not take BUPROPION if you:

- are taking WELLBUTRIN (bupropion HCl) Tablets or WELLBUTRIN SR (bupropion HCl) Sustained-Release Tablets.

- are taking any other medicines that contain bupropion HCl.

- have or have had a seizure disorder (for example, epilepsy).

- have or have had an eating disorder.

- are currently taking or have recently taken a monoamine oxidase inhibitor (MAOI).

- are allergic to bupropion HCl.


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